The present work describes zero absorbance spectrophotometric method for simultaneous estimation of ethamsylate and tranexamic acid in combined tablet dosage form. The developed method involve derivatization procedure for making tranexamic acid UV detectable. It employs development of zero absorbance method using two wavelengths 302.0 nm and 569 nm. The method obeys beer’s law in the employed concentration range of 20-70 μg ml-1 for both drugs. Results of analysis were validated statistically and by recovery studies.
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